Stem Cell : Programming and Reprogramming

Conference Title

Location

Day Month Year

Speaker

Konrad Hochedlinger

Konrad HochedlingerKonrad Hochedlinger is an Associate Professor at the Department of Stem Cell and Regenerative Medicine of Harvard University, a Principal Faculty at the Harvard Stem Cell Institute and an Investigator at the Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine. He received his B.Sc. in biology and his Ph.D. in genetics from the University of Vienna. From 1998-1999, he worked with Erwin Wagner at the Research Institute of Molecular Pathology in Vienna and from 2000-2006 as a Visiting Graduate Student and then Postdoc with Rudolf Jaenisch at the Whitehead Institute/MIT. During his stay at the Whitehead Institute, he worked on nuclear transfer in mice to show that terminally differentiated lymphocytes and malignant melanoma cells remain amenable to reprogramming into a pluripotent state. In his own lab, Dr. Hochedlinger continued work on nuclear reprogramming by focusing on a novel method that had been previously developed by Dr. Yamanaka and involves introducing defined transcription factors into somatic cells, generating induced pluripoent stem (iPS) cells. Dr. Hochedlinger’s lab reproduced and improved this technology and contributed to an understanding of its mechanism. For example, his team showed that iPS cells can be generated without the use of integrating viruses, thus eliminating a major roadblock for their potential use in therapy. He is currently using the mouse and human system to further elucidate the mechanisms of in vitro reprogramming. Dr. Hochedlinger is a Kimmel and V Scholar and has been awarded the NIH Director’s Innovator Award in 2007, the International Society of Stem Cell Research Young Investigator Award and the Howard Hughes Medical Institute Early Career Award in 2009.

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Supporting publications

Cell
Cell : Stem Cell
Trends in Pharmacological Sciences
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