Stem Cell : Programming and Reprogramming

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Speaker

Kenneth R. Chien

Kenneth R. ChienDr. Kenneth R. Chien is a world-recognized leader in cardiovascular science and medicine. Dr. Chien completed his undergraduate degree in Biology at Harvard College in Boston, Massachusetts in 1973. He further pursued his studies in Medicine at the Temple University School of Medicine in Philadelphia, Pennsylvania completing both his MD in 1980 and his PhD in 1983. Dr. Chien completed his internship and residency in Medicine at the Parkland Memorial Hospital in Dallas, Texas. He completed his clinical research fellowship in Cardiology at the University of Texas Southwestern Medical Center in Dallas, Texas and, subsequently, joined the faculty as Assistant Professor of Medicine in Cardiology in 1984. In 1988 Dr. Chien became Associate Professor of Medicine in the Department of Medicine and Member of the Center for Molecular Genetics at the University of California, San Diego. In 1992 Dr. Chien progressed as full Professor of Medicine and served as the Director of the Institute for Molecular Medicine at the University of California at San Diego and a Professor at the Salk Institute. Since July, 2005, Dr. Chien has returned to Boston as Scientific Director of the Cardiovascular Research Center at Massachusetts General Hospital and the Charles Addison and Elizabeth Ann Sanders Professor of Medicine in the Department of Stem Cell and Regenerative Biology at Harvard University in Cambridge, Massachusetts.

Dr. Chien’s laboratory has reported the discovery of a “master” heart progenitor cell, marked by the expression of Islet-1, in the mammalian heart, which play a critical role in generating diverse cardiovascular lineages during cardiogenesis. Recent studies have now led to the identification and purification of a primordial human islet-1 progenitor from human ES cells which give rise to a family of downstream intermediate multipotent heart progenitors that have been implicated in human congenital heart disease. In addition, his lab has generated, for the first time, a fully mature strip of ventricular muscle from ES cells, via combining tissue engineering and stem cell technology together. This approach opens the path towards the generation of heart parts for end stage cardiovascular diseases via controlling the cell fate of pluripotent human ES and iPS cells.

Dr. Chien has served as an advisor and/or board member to several scientific institutions in the public and private sector, including the Karolinska Institute, Doris Duke Charitable Foundation, The Wellcome Trust, The Institute of Molecular Biotechnology of Austria, Genentech, Hoffman La-Roche, Pfizer, GlaxoSmithKline, Wyeth, University of Edinburgh, and Oxford University. Dr. Chien also has strong interests in biotechnology and biomedical science in China, as well as the international exchange of physician-scientist training; he is the founder of the Institute of Molecular Medicine at Peking University. For his training efforts and his work, he has received several awards, including the Pasarow Foundation Award, an honorary Doctorate of Science from the University of Edinburgh, and recent election as a foreign member of the Austrian Academy of Sciences, and the Norwegian Academy of Sciences.

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Supporting publications

Cell
Cell : Stem Cell
Trends in Pharmacological Sciences
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